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. 2018 Mar 27;16:30. doi: 10.1186/s12951-018-0350-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Biotoxicity of nanoparticles: a cell viability assays of A549 cells treated with different samples, *for samples calculated by DOX content with the upper abscissa, b H&E staining images of histological sections with major organs after 48 h injection of 200 μL Mn-IOSP NCs (experimental group) or 200 μL PBS (control group)