Table 2.

Association of cleavage site motif types with KEGG functional terms

Test by peak shape	KEGG functional terms	p value	Number of genes in set with this function	Number of Cleavage Sites by KEGG Term
Global	Oxidative phosphorylation	4.90E-06	14	54
	Purine metabolism	2.08E-03	13	37
	Aminoacyl-tRNA biosynthesis	8.94E-03	7	16
	RNA polymerase	1.72E-02	3	19
	Pyrimidine metabolism	4.67E-02	8	26
	Protein export	4.93E-02	5	37
Sharp	Oxidative phosphorylation	2.60E-05	12	54
	Purine metabolism	1.13E-03	12	37
	RNA polymerase	9.13E-03	3	19
	Pyrimidine metabolism	1.14E-02	8	26
	Aminoacyl-tRNA biosynthesis	1.89E-02	6	16
Tail L	RNA polymerase	7.11E-05	3	19
	Protein export	1.24E-02	3	37
	Purine metabolism	1.39E-02	5	37
Tail R	RNA polymerase	4.52E-02	3	54
	Protein export	1.51E-02	2	37
Twin R	Oxidative phosphorylation	9.70E-04	5	54
	Protein export	1.03E-02	3	37
	Oxidative phosphorylation	2.52E-02	4	54
	Citrate cycle (TCA cycle)	4.94E-02	3	39

Certain cleavage site motifs are disproportionately located within genes that are associated with certain KEGG functional terms. The following table lists the KEGG terms associated with each cleavage site motif type and the p-values associated with each KEGG term. P-values were calculated from hypergeometric tests for KEGG pathways and Holm’s test was used to correct for multiple testing