Fig. 4. Differentiation-associated transcripts; NOTCH1-IL-6 and viral defense associated transcripts were downregulated in the TCGA bladder tumor cohort.

Normalized mRNA z-scores of TCGA bladder tumor data set revealed downregulation of (a) NOTCH1 and IL-6 transcripts, and (b). Viral defense transcripts. This downregulation occured independently of p53 expression and metastatic disease. Each row is a gene z-score and each column is an individual tumor sample. Red color indicates that the gene was expressed at a higher level than the gene with the green color code within the same tumor.