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. 2017 Dec 11;8(12):3200. doi: 10.1038/s41419-017-0041-4

Fig. 8. SP1–SK1–S1P signaling pathway is critical to the anti-necroptosis effect of hiPSC-MSCs-EVs against renal I/R injury in vivo.

Fig. 8

a Representative histopathologic images of kidney sections harvested at 48 h after reperfusion (H&E staining; scale bars, 100 μm). b Blood samples were collected, serum creatinine, blood urea nitrogen, MDA content, and SOD activity were evaluated. Data are presented as means ± SEM, n = 6 mice per group; statistical significance: *p < 0.05; **p < 0.01, ***p < 0.001