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. 2017 Dec 11;8(12):3200. doi: 10.1038/s41419-017-0041-4

Fig. 9. Schematic diagram of the proposed cellular mechanisms for the protection of hiPSC-MSCs-derived EVs after renal I/R injury.

Fig. 9

Based on our data, we propose that hiPSC-MSCs-EVs alleviate renal I/R injury by delivering SP1 to the target renal cells and resulting in intracellular activation of SK1 expression and generation of S1P, by which inhibits I/R-induced necroptosis