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. 2017 Dec 13;8(12):3212. doi: 10.1038/s41419-017-0017-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visithttp://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative western blot showing SiO₂-induced σ-1R upregulation in a time-dependent manner. b Densitometric analysis of σ-1R from five experiments; * p < 0.05 vs the control group. c SiO₂ upregulated collagen I and collagen III expression levels in a time-dependent manner. d Densitometric analysis of collagen I and collagen III from five experiments; * p < 0.05 vs the control group. e Representative immunocytochemical images showing that SiO₂ increased σ-1R and collagen III expression levels in HPF-a, which was attenuated by pretreatment of BD1047 (10 μM)