Fig. 2.

HRD1 expression is decreased in the kidneys of db/db mice. a Glomerulosclerosis and tubulointerstitial fibrosis were observed in a mouse model of diabetic nephropathy (DN; db/db mice) when compared with the control mice. b The HRD1 expression was tested using kidney tissues from db/db mice and control mice by western blot assays. c Quantitation of immunoblot data for HRD1 proteins as in (b). d The kidney expression of HRD1 was significantly decreased in the DN model as determined by immunohistochemical staining (×400). e The intensity of HRD1 expression was quantified. Bars are means ± S.E. from three independent experiments. **P < 0.01