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. 2017 Dec 11;8(12):3202. doi: 10.1038/s41419-017-0002-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — HRD1 overexpression prevents PA-induced apoptosis of HKC-8 cells. a Palmitic acid (PA) treatment significantly increased the expressions of cleaved PARP, cleaved caspase-3, and BAX, but decreased Bcl-2 expression. However, Ad-HRD1 infection suppressed the PA-induced expression of cleaved PARP, cleaved caspase-3, and BAX. b Quantitation of western blot data for protein expressions as in (a), normalized to actin expression. c TUNEL staining showed that Ad-HRD1 infection reduced the numbers of apoptotic HKC-8 cells compared to cells treated with PA. d The means of data of TUNEL-positive area as in (c). Bars are means ± S.E. from three independent experiments. n.s. means no significance, *P < 0.05