Fig. 2.

Outline of three-dimensional mass univariate framework. A statistical atlas provides point-wise measures of ventricular geometry and function which can be linked to a given predictor through a general linear model. Using mass univariate regression, three-dimensional maps of a test statistic and the degree of association (β) can be derived. Threshold free cluster enhancement (TFCE) coupled with permutation testing produces vertex-wise P-values weighted to the degree of coherent spatial support. Finally, P-values are corrected for multiple testing. Regression coefficients enclosed by significance contours are represented on a model of the left ventricle