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. 2018 Mar 23;11:1655–1664. doi: 10.2147/OTT.S145473

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© 2018 Boogerd et al. This work is published and licensed by Dove Medical Press Limited

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Tumor-to-normal tissue (T/N) ratio for CEA, EpCAM and c-Met on primary resected tumors.

Notes: Shown are correlations between tumor tissue and adjacent normal tissue in the same sample, per patient and per biomarker (both cohort 1 and cohort 2). All biomarkers were significantly upregulated in tumor tissue compared to adjacent normal epithelium. The T/N ratio was highest for CEA. The arrows indicate the number of tumor tissues that show an enhanced or decreased expression compared to adjacent normal epithelium; = refers to equal expression scores.

Abbreviations: TIS, total immunostaining score; CEA, carcinoembryonic antigen; EpCAM, epithelial cell adhesion molecule; c-Met, tyrosine-protein kinase Met.