Table 3.
Degree of concordance of biomarker expression between various tumor tissues per patient
| No CRT | CEA | EpCAM | c-Met |
|---|---|---|---|
| Biopsy = tumor | 22/36 (61%) | 22/36 (61%) | 28/36 (78%) |
| Biopsy > tumor | 5/36 (14%) | 2/36 (6%) | 2/36 (6%) |
| Biopsy < tumor | 9/36 (25%) | 12/36 (33%) | 6/36 (17%) |
| LN metastasis = tumor | 9/10 (90%) | 9/10 (90%) | 7/10 (70%) |
| LN metastasis > tumor | 1/10 (10%) | 1/10 (10%) | 1/10 (10%) |
| LN metastasis < tumor | 0/10 (0%) | 0/10 (0%) | 2/10 (10%) |
| CRT | |||
| Biopsy = tumor | 16/23 (70%) | 17/23 (74%) | 14/23 (61%) |
| Biopsy > tumor | 2/23 (9%) | 1/23 (4%) | 1/23 (4%) |
| Biopsy < tumor | 5/23 (22%) | 5/23 (22%) | 8/23 (35%) |
| LN metastasis = tumor | 6/7 (86%) | 7/7 (100%) | 4/7 (57%) |
| LN metastasis > tumor | 1/7 (14%) | 0/7 (0%) | 0/7 (0%) |
| LN metastasis < tumor | 0/7 (0%) | 0/7 (0%) | 3/7 (43%) |
Note: = Indicates a concordant expression between the two tissues, > indicates up regulation of expression, < indicates down regulation of expression.
Abbreviations: CRT, chemo- and radiotherapy; CEA, carcinoembryonic antigen; EpCAM, epithelial cell adhesion molecule; c-Met, tyrosine-protein kinase Met; LN, lymph node.