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. 2018 Mar 27;15:51. doi: 10.1186/s12985-018-0967-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Neutralizing antibodies titers to DENV-2 genotypes (Cosmopolitan, Asian I and Asian/American) in marmosets inoculated with candidate dengue vaccines and challenged with isolated DENV. Neutralizing antibody titers in marmosets inoculated with: a Candidate vaccine DENV-2 16,881 PDK-53, b Candidate vaccine DENV-2 16,881 PDK-53 in primary and with DENV-2 genotype Cosmopolitan in secondary, c Vaccine candidate DENV-1 16,007 PDK-13, d Vaccine candidate DENV-1 16,007 PDK-13 in primary and DENV-1 genotype I in secondary. Double asterisks (**) indicate that there were statistically significant differences (p < 0.05) in the titers of neutralizing antibodies between genotypes. Student’s test analysis was used to determine the differences in mean titers of neutralizing antibody between CM vs AI, CM vs AA, and AI vs AA. CM indicates Cosmopolitan genotype. A1 indicates Asian I genotype. AA indicates Asian/American genotype