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. 2018 Mar 27;15:51. doi: 10.1186/s12985-018-0967-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Neutralizing antibodies titers to DENV-2 genotypes (Cosmopolitan, Asian I and Asian/American) after tertiary inoculation. a Marmosets which had been first inoculated with DENV-2 16,881 PDK-53 (Asian I genotype) and then challenged with DENV-2 genotype Cosmopolitan were infected with DENV-1 in tertiary inoculation. b Neutralizing antibody titers to DENV-1, genotype 1 in the same marmosets in (a). c Marmosets that were first inoculated with the DENV-2 Asian I genotype and then challenged with the DENV-2 genotype Cosmopolitan were infected with DENV-1 genotype I in tertiary inoculation. d Neutralizing antibody titers to DENV-1, genotype 1 in the same marmosets in (c). Double asterisks (**) indicate that there were statistically significant differences (p < 0.05) in the titers of neutralizing antibodies between genotypes. Student’s test analysis was used to determine the differences in mean titers of neutralizing antibody between CM vs AI, CM vs AA, and AI vs AA. CM indicates Cosmopolitan genotype. A1 indicates Asian I genotype. AA indicates Asian/American genotype