Table 5.
Repeated measures analysis of combined age 5 and 8 years: Associations of lung function measurements in relation to weighted road density within a 50 m radius of home and stratified by fish oil supplementation restricted to non-movers between age 5 and 8 years
| No fish oil supplementation | Fish oil supplementation | p-value for interaction | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean Difference | 95% CI | p-value | N | Mean Difference | 95% CI | p-value | ||
| log(FEV1 pre bronchodilator (L)) | 114 | −0.06 | −0.11−0.02 | 0.009 | 101 | 0 | − 0.04−0.04 | 0.938 | 0.088 |
| log(FEV1 post bronchodilator (L)) | 111 | −0.04 | −0.08−0.00 | 0.050 | 100 | −0.01 | − 0.05−0.02 | 0.505 | 0.508 |
| log (FVC pre bronchodilator (L)) | 113 | −0.03 | −0.07−0.01 | 0.200 | 99 | 0 | −0.04−0.04 | 0.997 | 0.680 |
| log (FVC post bronchodilator (L)) | 110 | −0.01 | −0.05−0.03 | 0.587 | 98 | 0 | −0.04−0.03 | 0.846 | 0.843 |
| FEV1/FVC ratio pre bronchodilator | 113 | −0.03 | −0.05--0.01 | 0.014 | 99 | 0 | −0.02−0.02 | 0.979 | 0.031 |
| FEV1/FVC ratio post bronchodilator | 110 | −0.02 | −0.04−0.01 | 0.010 | 98 | −0.01 | −0.02−0.01 | 0.239 | 0.139 |
| pre Peak Expiratory Flow (PEF) | 91 | 4.33 | −4.09−12.75 | 0.313 | 85 | −0.55 | −7.14−6.04 | 0.871 | 0.252 |
| post Peak Expiratory Flow (PEF) | 90 | 8.46 | −0.07−16.98 | 0.051 | 84 | −2.57 | −9.29−4.14 | 0.453 | 0.056 |
| Pre forced expiratory flow at 50% vital capacity (FEF50) | 91 | −0.09 | −0.22−0.05 | 0.227 | 85 | 0.01 | −0.11−0.13 | 0.893 | 0.380 |
| Post forced expiratory flow at 50% vital capacity (FEF50) | 90 | −0.08 | −0.23−0.08 | 0.333 | 84 | −0.09 | −0.22−0.04 | 0.19 | 0.757 |
| Pre forced expiratory flow at mid-expiratory phase (FEF25–75) | 91 | −0.07 | −0.18−0.05 | 0.270 | 85 | −0.02 | −0.12−0.08 | 0.743 | 0.747 |
| Post forced expiratory flow at mid-expiratory phase (FEF25–75) | 90 | −0.03 | −0.16−0.11 | 0.701 | 84 | −0.08 | −0.20−0.03 | 0.161 | 0.369 |
All models are adjusted for age at spirometry, height at spirometry, weight at spirometry, sex, father’s education, mother’s education, environmental tobacco smoke exposure, breastfed to 6 months, any dog owned by 5 or 8 years, any cat owned by 5 or 8 years, maternal smoking in pregnancy, gas cooking at home
Interaction term of fish oil supplementation with weighted road density was added as a separate term into a random intercept Poisson model. Mean difference, Relative Risks (RRs) and 95% confidence intervals (95% CI) represent increase in risk per unit increase in weighted road density, representing 100 m local road or 33.3 m of motorway within 50 m of the home. N = number of children