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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Biochem Soc Trans. 2017 Sep 12;45(5):1159–1171. doi: 10.1042/BST20170096

Figure 1. Structures of superfamily 1B helicases.

Figure 1

(A) Domain maps of SF1B helicases. N-terminal domains are shown in blue, helicase domains in gray, C-terminal domains in orange, and the Pif1 signature sequence in pink. (B) Structure of hPIF1-HD (PDB: 5FHH) [33]. Domain 1A is shown in green, 1B in red, 2A in gray, 2B in cyan, and the Pif1 signature sequence in pink. ADP-AlF4− is shown in purple. (C) Structure of BsPif1 (PDB: 5FTE) [32]. Colors are the same as in B with the C-terminal domain in orange, AMPPNP in purple, and DNA is in yellow. (D) Structure of BaPif1 (PDB: 5FHD) [33]. Colors are as in B with DNA shown in yellow. (E) Structure of D. radiodurans RecD2 (PDB: 3GPL) [34]. Colors are the same as in B with the N-terminal domain in blue, AMPPNP in purple, and DNA in yellow. (F) Structure of Bacteriophage T4 Dda (PDB: 3UPU) [35]. Colors are as in B with DNA in yellow.