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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Biochem Soc Trans. 2017 Sep 12;45(5):1159–1171. doi: 10.1042/BST20170096

Figure 2. Structure of the Pif1 signature sequence.

Figure 2

Hydrophobic amino acids in the BaPif1 (PDB: 5FHD) [33] signature sequence (pink) interact with amino acids in domains 1A (green) and 1B (red) stabilizing this region of the protein. Ile118 which is essential for helicase activity [33] and corresponds to L319 in hPIF1 is shown in blue. DNA is shown in yellow.