TABLE 2.
Associations of Combinations of MyD88 and TLR4 Expression With Overall Survival Among Cases With the 5 Most Common Invasive Epithelial Ovarian Cancer Histotypesa,b
| Histotype | MyD88 | TLR4 | Subjects, n | No. of events | HR (95% CI) | P |
|---|---|---|---|---|---|---|
| High-grade serous | Weak | Weak | 246 | 149 | Reference | .10 |
| Strong | 323 | 217 | 1.15 (0.92–1.42) | |||
| Strong | Weak | 450 | 312 | 1.23 (1.01–1.51) | ||
| Strong | 1414 | 991 | 1.25 (1.04–1.50) | |||
|
| ||||||
| Endometrioid | Weak | Weak | 85 | 22 | Reference | .72 |
| Strong | 103 | 27 | 1.18 (0.65–2.13) | |||
| Strong | Weak | 75 | 23 | 1.40 (0.75–2.63) | ||
| Strong | 339 | 78 | 1.08 (0.65–1.79) | |||
|
| ||||||
| Clear cell | Weak | Weak | 162 | 64 | Reference | .82 |
| Strong | 61 | 21 | 1.18 (0.70–1.99) | |||
| Strong | Weak | 168 | 77 | 1.18 (0.82–1.69) | ||
| Strong | 162 | 70 | 1.10 (0.76–1.60) | |||
|
| ||||||
| Mucinous | Weak | Weak | 28 | 14 | Reference | .52 |
| Strong | 43 | 13 | 1.73 (0.71–4.26) | |||
| Strong | Weak | 44 | 23 | 1.05 (0.46–2.40) | ||
| Strong | 178 | 57 | 1.43 (0.64–3.20) | |||
|
| ||||||
| Low-grade serous | Weak | Weak | 17 | 10 | Reference | .02 |
| Strong | 14 | 8 | 0.87 (0.28–2.71) | |||
| Strong | Weak | 24 | 11 | 0.78 (0.28–2.21) | ||
| Strong | 84 | 45 | 0.33 (0.13–0.85) | |||
a
HR = hazard ratio; MyD88 = myeloid differentiation primary response gene 88; TLR4 = Toll-like receptor 4.
b
Adjusted for study, age (continuous), and stage (I/II, III/IV, unknown). P values from unordered 3 degree-of-freedom test.