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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):528–532. doi: 10.1038/nature23910

Extended Data Figure 4. Poly(I:C)-induced inflammation during pregnancy, not after giving birth, is critical in inducing MIA-associated behavioral abnormalities in offspring.

Extended Data Figure 4

a, Schematic of the experimental design for cross-fostering experiments. b, USV index (n=21/20 (PBS dams;PBS/poly(I:C) pups); n=22/15 (poly(I:C) dams;PBS/poly(I:C) pups); 2-4 independent experiments). c-g Marble-burying index (c), time spent in the center of an open field (d), and % interaction (e), total investigation time (f), and total distance traveled (g) during the sociability test (n=9/14 (PBS dams;PBS/poly(I:C) pups); n=12/10 (poly(I:C) dams;PBS/poly(I:C) pups); 2 independent experiments). **p<0.01, ****p <0.0001 as calculated by one-way (b-d,f-g) and two-way (e) ANOVA with Tukey post-hoc tests. N.S., not significant. Graphs indicate mean +/− s.e.m.