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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):528–532. doi: 10.1038/nature23910

Extended Data Figure 5. Composition of maternal gut microbiota during pregnancy, not after giving birth, is critical in inducing MIA-associated behavioral abnormalities in offspring.

Extended Data Figure 5

a, Schematic of the experimental design for cross-fostering experiments. b, USV index (n=9/36 (Tac pups with Jax dams;PBS/poly(I:C)); n=10/24 (Jax pups with Tac dams;PBS/poly(I:C)); 2-4 independent experiments). c-g, Marble-burying index (c), time spent in the center of an open field (d), and % interaction (e), total investigation time (f), and total distance traveled (g) during the sociability test (n=7/22 (Tac pups with Jax dams;PBS/poly(I:C)); n=7/21 (Jax pups with Tac dams;PBS/poly(I:C)); 2 independent experiments). *p<0.05, **p<0.01, ***p<0.001, ****p <0.0001 as calculated by one-way (b-d,f-g) and two-way (e) ANOVA with Tukey post-hoc tests. Graphs indicate mean +/− s.e.m.