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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):528–532. doi: 10.1038/nature23910

Extended Data Figure 9. The IL-17a pathway promotes abnormal behavioral phenotypes in MIA offspring born to mice colonized with human commensal bacteria.

Extended Data Figure 9

a, Schematic representation of the experimental design. b, Quantification of bacterial colonization levels through colony forming unit (CFU) counts or qPCR analyses. c, USV index (n=13/12/28/16/17/14 (poly(I:C);vehicle/SFB/Listeria monocytogenes/Bacteroides fragilis/Bifidobacterium adolescentis/CD-SpA 2A). d-e, Maternal plasma concentrations of IL-17a/IFN-γ at E14.5 (n=4/4/3/6/3 (poly(I:C);vehicle/Listeria monocytogenes/Bacteroides fragilis/Bifidobacterium adolescentis/CD-SpA 2A). f, qPCR analysis measuring relative SFB levels in Jax mice gavaged with various bacteria; from two independent experiments. *p<0.05, ****p<0.0001 as calculated by one-way (c-f) ANOVA with Tukey post-hoc tests and Student’s t-test (b). N.D., not determined. N.S., not significant. Graphs indicate mean +/− s.e.m.