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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Feb 16;28(6):1011–1019. doi: 10.1016/j.bmcl.2018.02.031

Scheme 2.

Scheme 2

Synthesis of oxadiazole containing α-synuclein compounds. Reagents and conditons: (a) NH2OH HCl, EtOH/H2O (2/1, v/v), NaHCO3; (b) AlCl3, ClCH2CH2Cl; (c) Cs2CO3, THF, 70 °C, TsOCH2CH2F for 20, MeOCH2Cl for 21, CHBr(CH3)2 for 22; (d) EDCl·HCl, HOBt, DIPEA, DMF, 130 °C.