| Up in trisomic iPSCs |
|
|
|
Down in trisomic iPSCs |
|
|
|
| Functional cluster #1 |
Fold Enrichment |
PValue |
FDR |
Functional cluster #1 |
Fold Enrichment |
P Value |
FDR |
| transmission of nerve impulse |
3.96 |
8.90E-16 |
1.54E-12 |
cell adhesion |
2.75 |
2.03E-12 |
3.55E-09 |
| synaptic transmission |
3.88 |
6.27E-13 |
1.09E-09 |
biological adhesion |
2.74 |
2.12E-12 |
3.71E-09 |
| cell-cell signaling |
2.84 |
8.56E-13 |
1.49E-09 |
homophilic celladhesion |
5.38 |
6.15E-10 |
1.08E-06 |
| neurological system process |
1.74 |
2.92E-06 |
0.005092592 |
cell-cell adhesion |
3.14 |
5.10E-07 |
8.92E-04 |
| Functinal cluster #2 |
|
|
|
Functional cluster #2 |
|
|
|
| regulation of system process |
3.37 |
5.80E-10 |
1.01E-06 |
gastrulation |
6.87 |
2.54E-08 |
4.44E-05 |
| regulation o ftransmission of nerve impulse |
4.52 |
6.31E-09 |
1.10E-05 |
formation of primary germ layer |
8.82 |
2.81E-07 |
4.92E-04 |
| regulation of neurological system process |
4.35 |
1.35E-08 |
2.34E-05 |
embryonic morphogenesis |
3.03 |
3.60E-07 |
6.29E-04 |
| regulation of synaptic transmission |
4.46 |
4.20E-08 |
7.32E-05 |
pattern specification process |
3.12 |
9.48E-07 |
0.001657046 |
| regulation of synaptic plasticity |
3.61 |
0.006351579 |
10.5118869 |
mesoderm morphogenesis |
8.44 |
1.84E-06 |
0.003213325 |
|
|
|
|
mesoderm development |
5.63 |
2.70E-06 |
0.0047194 |
| Functinal cluster #3 |
|
|
|
mesoderm formation |
8.01 |
1.16E-05 |
0.02024587 |
| neuron differentiation |
3.17 |
3.89E-12 |
6.77E-09 |
anterior/posterior pattern formation |
3.66 |
3.04E-05 |
0.053073992 |
| neuron development |
3.15 |
1.93E-09 |
3.37E-06 |
regionalization |
3.09 |
4.39E-05 |
0.07681769 |
| cell morphogenesis involved in differentiation |
3.55 |
6.04E-09 |
1.05E-05 |
tissue morphogenesis |
3.03 |
1.60E-04 |
0.278911765 |
| cell morphogenesis involved in neuron differentiation |
3.60 |
6.05E-08 |
1.06E-04 |
tube morphogenesis |
3.03 |
0.002034975 |
3.499102339 |
| cell morphogenesis |
2.84 |
7.80E-08 |
1.36E-04 |
embryonic development ending in birth or egg hatching |
1.92 |
0.008574202 |
13.97796428 |
| neuron projection morphogenesis |
3.53 |
8.80E-08 |
1.53E-04 |
chordate embryonic development |
1.84 |
0.015827991 |
24.3434896 |
| cell projection morphogenesis |
3.30 |
9.94E-08 |
1.73E-04 |
|
|
|
|
| cell part morphogenesis |
3.16 |
2.47E-07 |
4.31E-04 |
Functional cluster #3 |
|
|
|
| neuron projection development |
3.16 |
2.47E-07 |
4.31E-04 |
smooth muscle contraction |
8.74 |
5.77E-06 |
0.010082818 |
| axonogenesis |
3.44 |
8.72E-07 |
0.001520019 |
muscle contraction |
3.14 |
3.01E-04 |
0.525109932 |
| cellular component morphogenesis |
2.55 |
1.02E-06 |
0.001771102 |
muscle system process |
2.86 |
7.74E-04 |
1.344891904 |
| cell projection organization |
2.51 |
4.34E-06 |
0.007560515 |
|
|
|
|
| axon guidance |
3.51 |
3.15E-04 |
0.547811961 |
|
|
|
|
| cell motion |
1.95 |
5.13E-04 |
0.891166229 |
|
|
|
|
| Up in trisomic neuronal culture |
|
|
Down in trisomic neuronal culture |
|
|
| Functional cluster #1 |
Fold Enrichment |
PValue |
FDR |
Functional cluster #1 |
Fold Enrichment |
PValue |
FDR |
| gamma-aminobutyric acid signaling pathway |
29.41 |
3.09E-04 |
0.481161011 |
celadhesion |
2.56 |
6.45E-18 |
1.17E-14 |
| neurological system process |
1.94 |
0.014631542 |
20.55054889 |
biologicaadhesion |
2.56 |
7.10E-18 |
1.29E-14 |
| synaptic transmission |
3.45 |
0.01518596 |
21.24538095 |
cell-celadhesion |
2.34 |
5.88E-06 |
0.010659657 |
| transmission of nerve impulse |
2.94 |
0.030529405 |
38.36333371 |
|
|
|
|
| cell-cell signaling |
2.21 |
0.048634045 |
54.07387315 |
Functional cluster #2 |
|
|
|
|
|
|
|
bloovessedevelopment |
3.24 |
2.11E-11 |
3.82E-08 |
| Functional cluster #2 |
|
|
|
vasculaturdevelopment |
3.17 |
4.71E-11 |
8.53E-08 |
| cell adhesion |
2.31 |
0.018959843 |
25.82606353 |
angiogenesis |
4.00 |
5.25E-11 |
9.52E-08 |
| biological adhesion |
2.31 |
0.019129339 |
26.02582494 |
bloovessemorphogenesis |
3.24 |
6.71E-10 |
1.22E-06 |
| cell-cell adhesion |
2.66 |
0.115339039 |
85.23209769 |
|
|
|
|
|
|
|
|
Functional cluster #3 |
|
|
|
| Functional cluster #3 |
|
|
|
extracellular matrix organization |
4.44 |
1.01E-09 |
1.82E-06 |
| mechanical stimulus involved in sensory perception |
33.93 |
0.003326548 |
5.067655192 |
collagen fibril organization |
7.65 |
1.50E-07 |
2.72E-04 |
| detection of mechanical stimulus |
27.57 |
0.005051111 |
7.599250716 |
extracellular structure organization |
3.06 |
6.24E-07 |
0.001130422 |
