Table 2. Comparable studies assaying transcriptome differences in isogenic disomic/trisomic iPSCs pairs.

study	isogenic iPSC approach	sex	transforming factors	culture	transcriptome analysis
Li et al, 2012 [12] (used in this study)	genetic selection for Chr21 loss	M	LIN28, NANOG, SOX2, OCT4	feeder-free	RNA-seq
Weick et al, 2013 [13]	fibroblasts from mosaic individual	M	OCT4, SOX2, KLF4, MYC	MEFs	microarray
Jiang et al, 2013 [14]	inducible XIST inactivation of one Chr 21	M	OCT4, SOX2, KLF4, MYC	MEFs	microarray
Letourneau et al, 2014 [15]	fibroblasts from dischordant twin pair	F	OCT4, SOX2, KLF4, MYC	Human foreskin	RNA-seq