Table 1. Clinical and serologic variables of the studied subjects.

	Healthy Relatives		RA patients	P value
	Anti-CCP2+ N = 12	Anti-CCP2- N = 12	N = 10
Age, yrs., mean ± SD	35 ± 8.7	43 ± 14.8	41 ± 9.8	0.257
Female (%)	75	91	80	0.534
Anti-CCP2 (U/ml), mean ± SD)	35 ± 5.4*	13 ± 1.7	194 ± 238.9*	0.0001
FR (IU/ml, mean ± SD)	6 ±3.5	7 ± 9.1	181 ± 178.2*	<0.0001
DAS28	NA	NA	5.8 ± 1.2	-

*Indicates significant differences for the anti-CCP2- group.