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. 2018 Mar 27;13(3):e0194205. doi: 10.1371/journal.pone.0194205

Table 2. Biological processes in ACCP+ and rheumatoid arthritis (RA) groups of up-regulated genes by Gene ontology (GO) analysis.

Up-regulated GO in relatives with ACCP+ N, entities
 • Innate immune response 33
 • Interferon type 1 response 5
 • Interferon gamma response 10
 • Leukocyte activation 17
 • Leukocyte migration 12
 • Myeloid lineage differentiation 12
 • Leukocyte differentiation 10
 • Purine-containing compound catabolic process 24
 • Cellular response to cytokine stimulus 25
 • Cellular response to organonitrogen compounds 18
 • Cellular response to hormones 20
 • Chemotaxis 23
 • Cellular response to insulin stimulus 10
 • Cellular response to chemical stimulus 88
Up-regulated GO in patients with RA, N, entities
 • Inflammatory response 8
 • Cell projection organization 21
 • Signal transduction 89
 • Cellular response to chemical stimulus 41
 • Defense response 27
 • Immune response 19
 • Cellular response to stress 29
 • Regulation of metabolic process 122
 • Positive regulation of immune system process 17
 • Cell surface receptor signaling pathway 49
 • Cellular protein modification process 56
 • Brain development 21
 • Cellular nitrogen compound metabolic process 72