Table 3. Relative expression by RT-qPCR of 9 inflammatory up-regulated genes.
| First-degree relatives ACCP-(n = 12) | First-degree relatives ACCP+(n = 12) | RA(n = 7) | P-Value | |
|---|---|---|---|---|
| BCL2 | 0.45±0.36 | 0.48±0.43 | 0.87±0.30 | 0.0593 |
| SERPINGB9 | 0.45±0.40* | 0.50±0.20* | 1.02±0.53 | 0.0075 |
| SERPING1 | 0.84±0.91 | 0.96±1.25 | 0.25±0.32 | 0.3059 |
| SNCA | 0.37±0.28 | 0.72±0.74 | 1.32±0.88 | 0.1560 |
| MS4A1 | 0.31±0.34* | 0.40±0.24* | 1.45±0.88 | <0.0001 |
| ETS1 | 0.53±0.47* | 0.61±0.35* | 1.3±0.38 | <0.011 |
| EGR1 | 0.51±0.50* | 1.61±2.03* | 5.01±4.9 | 0.0042 |
| CX3CL1 | 5.66±7.49 | 1.79±2.04 | 0.07±0.09 | 0.0460 |
| MEF2A | 0.3292±0.31* | 0.4733±0.31* | 1.048±0.69 | 0.0041 |
Values represent mean ± SD; comparison between groups was performed using the Kruskal-Wallis test or ANOVA when necessary. Two-tail p value less than 0.05 was considered significant.
* indicates differences when compared with RA group.