Table 3. Analytic results of the IL-17A rs2275913 polymorphism.
Genotype | G/G n = 11 | G/A n = 86 | A/A n = 18 | p | OR [95% CI] |
---|---|---|---|---|---|
Mean onset age | 39.27 ± 16.24 | 42.72 ± 14.11 | 36.44 ± 15.32 | 0.225 | _ |
Mean DAS28 | 5.39 ± 1.37 | 5.87 ± 1.72 | 6.04 ± 1.66 | 0.923 | _ |
DAS28 > 5,1 n (%) | 7 (63.6%) | 57 (66.3%) | 15 (83.3%) | 0.34 | _ |
Subcutaneous nodules n(%) | 1 (9.1%) | 15 (17.6%) | 7 (38.9%)a | 0.029 | 3.22 [0.95–10.86] |
Bone lesion n (%) | 6 (54.5%) | 40 (46.5%) | 10 (55.6%) | 0.721 | _ |
Bone erosions n (%) | 1 (9.1%) | 27 (31.4%) | 5 (27.8%) | 0.13 | _ |
Osteoporosis n (%) | 5 (45.5%)b | 13 (15.1%) | 5 (27.8%) | 0.041 | 3.98 [0.92–17.07] |
ACCPA + n (%) | 9 (81.8%) | 61 (70.9%) | 11 (61.1%) | 0.485 | _ |
Mean ACCPA level RU/ml | 81.58 | 58.35 | 61.61 | 0.446 | _ |
RF + n (%) | 9 (81.8%) | 56 (75.7%) | 13 (72.2%) | 0.843 | _ |
RF > 100 IU/ml n (%) | 8 (72.7%) | 44 (60.3%) | 11 (61.1%) | 0.931 | _ |
IgM-RF + n (%) | 7 (63.6%) | 51 (68.9%) | 13 (72.2%) | 0.889 | _ |
Mean IgM-RF level IU/ml | 150.91 | 114 | 165.94 | 0.482 | _ |
IgA-RF + n (%) | 8 (72.7%) | 44 (59.5%) | 9 (50%) | 0.48 | _ |
Mean IgM-RF level IU/ml | 314.55 | 190.54 | 192.78 | 0.283 | _ |
Plasma IL-17A level pg/ml | 59.18 | 52.3 | 65.8 | 0.705 | _ |
a Chosen IL-17A genotype compared with the 2 other genotypes
bChosen IL-17A genotype compared with the 2 other genotypes