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. 2018 Mar 27;13(3):e0194883. doi: 10.1371/journal.pone.0194883

Table 3. Analytic results of the IL-17A rs2275913 polymorphism.

Genotype G/G n = 11 G/A n = 86 A/A n = 18 p OR [95% CI]
Mean onset age 39.27 ± 16.24 42.72 ± 14.11 36.44 ± 15.32 0.225 _
Mean DAS28 5.39 ± 1.37 5.87 ± 1.72 6.04 ± 1.66 0.923 _
DAS28 > 5,1 n (%) 7 (63.6%) 57 (66.3%) 15 (83.3%) 0.34 _
Subcutaneous nodules n(%) 1 (9.1%) 15 (17.6%) 7 (38.9%)a 0.029 3.22 [0.95–10.86]
Bone lesion n (%) 6 (54.5%) 40 (46.5%) 10 (55.6%) 0.721 _
Bone erosions n (%) 1 (9.1%) 27 (31.4%) 5 (27.8%) 0.13 _
Osteoporosis n (%) 5 (45.5%)b 13 (15.1%) 5 (27.8%) 0.041 3.98 [0.92–17.07]
ACCPA + n (%) 9 (81.8%) 61 (70.9%) 11 (61.1%) 0.485 _
Mean ACCPA level RU/ml 81.58 58.35 61.61 0.446 _
RF + n (%) 9 (81.8%) 56 (75.7%) 13 (72.2%) 0.843 _
RF > 100 IU/ml n (%) 8 (72.7%) 44 (60.3%) 11 (61.1%) 0.931 _
IgM-RF + n (%) 7 (63.6%) 51 (68.9%) 13 (72.2%) 0.889 _
Mean IgM-RF level IU/ml 150.91 114 165.94 0.482 _
IgA-RF + n (%) 8 (72.7%) 44 (59.5%) 9 (50%) 0.48 _
Mean IgM-RF level IU/ml 314.55 190.54 192.78 0.283 _
Plasma IL-17A level pg/ml 59.18 52.3 65.8 0.705 _

a Chosen IL-17A genotype compared with the 2 other genotypes

bChosen IL-17A genotype compared with the 2 other genotypes