Table 3.
Distributions of the three SNPs and laboratory results of sCJD patients.
| Laboratory tests |
Clinical tests |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein 14-3-3 in CSF |
EEG |
MRI |
|||||||||||
| SNP | n (%) | Positive (%) | Negative (%) | p Value | n (%) | Positive (%) | Negative (%) | p Value | n (%) | Positive (%) | Negative (%) | p Value | |
| Rs2910164 | CC | 172 (34.8) | 131 (33.8) | 41 (38.7) | \ | 127 (35.3) | 77 (35.0) | 50 (35.7) | \ | 131 (35.9) | 64 (37.0) | 67 (34.9) | \ |
| GC | 236 (47.8) | 184 (47.4) | 52 (49.1) | 0.668 | 167 (46.4) | 103 (46.8) | 64 (45.7) | 0.855 | 168 (46.0) | 78 (45.1) | 90 (46.9) | 0.677 | |
| GG | 86 (17.4) | 73 (18.8) | 13 (12.2) | 0.105 | 66 (18.3) | 40 (18.2) | 26 (18.6) | 0.997 | 66 (18.1) | 31 (17.9) | 35 (18.2) | 0.803 | |
| C | 580 (58.7) | 446 (57.5) | 134 (63.2) | \ | 421 (58.5) | 257 (58.4) | 164 (58.6) | \ | 430 (58.9) | 206 (59.5) | 224 (58.3) | \ | |
| G | 408 (41.3) | 330 (42.5) | 78 (36.8) | 0.133 | 299 (41.5) | 183 (41.6) | 116 (41.4) | 0.966 | 300 (41.1) | 140 (40.5) | 160 (41.7) | 0.741 | |
| Rs57095329 | AA | 324 (64.7) | 237 (61.7) | 87 (74.4) | \ | 229 (64.0) | 144 (65.2) | 85 (62.0) | \ | 233 (64.2) | 106 (60.9) | 127 (67.2) | \ |
| AG | 164 (32.7) | 135 (35.2) | 29 (24.8) | 0.025 | 117 (32.7) | 67 (30.3) | 50 (36.5) | 0.312 | 117 (32.2) | 59 (33.9) | 58 (30.7) | 0.384 | |
| GG | 13 (2.6) | 12 (3.1) | 1 (0.8) | 0.222 | 12 (3.3) | 10 (4.5) | 2 (1.5) | 0.259 | 13 (3.6) | 9 (5.2) | 4 (2.1) | 0.166 | |
| A | 812 (81.0) | 609 (79.3) | 203(86.8) | \ | 575 (80.3) | 355 (80.3) | 220 (80.3) | \ | 583 (80.3) | 271 (77.9) | 312 (82.5) | \ | |
| G | 190 (19.0) | 159 (20.7) | 31 (13.2) | 0.011 | 141 (19.7) | 87 (19.7) | 54 (19.7) | 0.994 | 143 (19.7) | 77 (22.1) | 66 (17.5) | 0.114 | |
| Rs295301 | GG | 187 (37.5) | 145 (37.7) | 42 (36.8) | \ | 137 (38.4) | 85 (38.6) | 52 (38.0) | \ | 136 (37.2) | 65 (37.6) | 71 (37.0) | \ |
| GA | 229 (45.9) | 173 (44.9) | 56 (49.1) | 0.634 | 163 (45.7) | 101 (45.9) | 62 (45.3) | 0.989 | 163 (44.7) | 76 (43.9) | 87 (45.3) | 0.841 | |
| AA | 83 (16.6) | 67 (17.4) | 16 (14.1) | 0.558 | 57 (15.9) | 34 (15.5) | 23 (16.7) | 0.756 | 66 (18.1) | 32 (18.5) | 34 (17.3) | 0.927 | |
| G | 603 (60.4) | 463 (60.1) | 140 (61.4) | \ | 437 (61.2) | 271 (61.6) | 166 (60.6) | \ | 435 (59.6) | 206 (59.5) | 229 (59.6) | \ | |
| A | 395 (39.6) | 307 (39.9) | 88 (38.6) | 0.729 | 277 (38.8) | 169 (38.4) | 108 (39.4) | 0.788 | 295 (40.4) | 140 (40.5) | 155 (40.4) | 0.979 | |