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. 2018 Feb 13;9(19):14764–14790. doi: 10.18632/oncotarget.24483

Table 1. 23 top hits that show >80% inhibition and 5 additional compounds of interest.

hM1-CAF hM1-2D
Drug Name Final EC50 (M) Averaged Max % Response StdDev Max % Response Final EC50 (M) Averaged Max % Response StdDev Max % Response
Dasatinib 58.9E-9 80 0.58 9.4E-9 83.75 0.35
Mithramycin 157.6E-9 93 2.56 174.1E-9 89.32 0.56
Teniposide 74.7E-9 94 0.50 482.6E-9 89.59 1.74
Methylrosanilinium 499.3E-9 101 0.06 489.1E-9 93.04 0.98
Gemcitabine 1.7E-9 96 9.21E-3 760.6E-12 93.78 0.29
Dactinomycin 3.8E-9 99 0.67 1.7E-9 94.30 0.29
Aclarubicin 610.8E-9 96 0.30 475.1E-9 94.77 0.76
Emetine 182.3E-9 100 0.18 118.3E-9 94.99 0.33
Epirubicin 84.5E-9 97 0.51 179.1E-9 95.41 0.84
Daunorubicin 38.8E-9 98 0.31 100.4E-9 95.59 0.60
Homoharringtonine 17.1E-9 99 0.20 14.1E-9 96.16 0.31
Topotecan 32.6E-9 97 0.08 312.8E-9 96.72 0.81
Idarubicin 10.7E-9 97 0.34 72.2E-9 96.85 0.51
Doxorubicin 90.6E-9 100 0.15 181.6E-9 96.89 1.07
Disulfiram 184.8E-9 59 12.08 316.6E-9 97.93 1.01
Dipyrithione magnesium sulfate 459.6E-9 93 6.61 428.8E-9 98.97 0.18
Bortezomib 1.4E-9 99 0.13 2.3E-9 99.25 0.14
Carfilzomib 2.6E-9 101 0.13 4.E-9 99.39 0.06
Romidepsin 952.8E-12 100 0.11 701.E-12 99.55 0.10
Auranofin 684.E-9 99 0.21 400.9E-9 99.55 0.07
Phanquinone 310.3E-9 99 1.14 105.8E-9 99.68 0.22
Thiram 596.4E-9 82 7.34 386.8E-9 100.10 0.07
Tyrothricin 407.2E-9 101 9.98E-3 491.5E-9 100.92 0.09
Afatinib 2.8E-6 94 3.05 226.3E-9 78.23 2.26
Neratinib 5.E-6 34 6.04 516.3E-9 67.78 1.49
Trametinib 5.E-6 38 5.35 2.7E-9 70.89 0.65
Oxaliplatin 5.E-6 11 2.82 5.E-6 10.49 2.86
Fluorouracil 5.E-6 33 9.34 5.E-6 45.58 2.18