Table 1. 23 top hits that show >80% inhibition and 5 additional compounds of interest.
hM1-CAF | hM1-2D | |||||
---|---|---|---|---|---|---|
Drug Name | Final EC50 (M) | Averaged Max % Response | StdDev Max % Response | Final EC50 (M) | Averaged Max % Response | StdDev Max % Response |
Dasatinib | 58.9E-9 | 80 | 0.58 | 9.4E-9 | 83.75 | 0.35 |
Mithramycin | 157.6E-9 | 93 | 2.56 | 174.1E-9 | 89.32 | 0.56 |
Teniposide | 74.7E-9 | 94 | 0.50 | 482.6E-9 | 89.59 | 1.74 |
Methylrosanilinium | 499.3E-9 | 101 | 0.06 | 489.1E-9 | 93.04 | 0.98 |
Gemcitabine | 1.7E-9 | 96 | 9.21E-3 | 760.6E-12 | 93.78 | 0.29 |
Dactinomycin | 3.8E-9 | 99 | 0.67 | 1.7E-9 | 94.30 | 0.29 |
Aclarubicin | 610.8E-9 | 96 | 0.30 | 475.1E-9 | 94.77 | 0.76 |
Emetine | 182.3E-9 | 100 | 0.18 | 118.3E-9 | 94.99 | 0.33 |
Epirubicin | 84.5E-9 | 97 | 0.51 | 179.1E-9 | 95.41 | 0.84 |
Daunorubicin | 38.8E-9 | 98 | 0.31 | 100.4E-9 | 95.59 | 0.60 |
Homoharringtonine | 17.1E-9 | 99 | 0.20 | 14.1E-9 | 96.16 | 0.31 |
Topotecan | 32.6E-9 | 97 | 0.08 | 312.8E-9 | 96.72 | 0.81 |
Idarubicin | 10.7E-9 | 97 | 0.34 | 72.2E-9 | 96.85 | 0.51 |
Doxorubicin | 90.6E-9 | 100 | 0.15 | 181.6E-9 | 96.89 | 1.07 |
Disulfiram | 184.8E-9 | 59 | 12.08 | 316.6E-9 | 97.93 | 1.01 |
Dipyrithione magnesium sulfate | 459.6E-9 | 93 | 6.61 | 428.8E-9 | 98.97 | 0.18 |
Bortezomib | 1.4E-9 | 99 | 0.13 | 2.3E-9 | 99.25 | 0.14 |
Carfilzomib | 2.6E-9 | 101 | 0.13 | 4.E-9 | 99.39 | 0.06 |
Romidepsin | 952.8E-12 | 100 | 0.11 | 701.E-12 | 99.55 | 0.10 |
Auranofin | 684.E-9 | 99 | 0.21 | 400.9E-9 | 99.55 | 0.07 |
Phanquinone | 310.3E-9 | 99 | 1.14 | 105.8E-9 | 99.68 | 0.22 |
Thiram | 596.4E-9 | 82 | 7.34 | 386.8E-9 | 100.10 | 0.07 |
Tyrothricin | 407.2E-9 | 101 | 9.98E-3 | 491.5E-9 | 100.92 | 0.09 |
Afatinib | 2.8E-6 | 94 | 3.05 | 226.3E-9 | 78.23 | 2.26 |
Neratinib | 5.E-6 | 34 | 6.04 | 516.3E-9 | 67.78 | 1.49 |
Trametinib | 5.E-6 | 38 | 5.35 | 2.7E-9 | 70.89 | 0.65 |
Oxaliplatin | 5.E-6 | 11 | 2.82 | 5.E-6 | 10.49 | 2.86 |
Fluorouracil | 5.E-6 | 33 | 9.34 | 5.E-6 | 45.58 | 2.18 |