Table 1. List of genes representing the resistant genetic signature.
Gene ID | Gene name | logFC | FDR |
---|---|---|---|
CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 9.9 | 1.77E-19 |
IGFBP7 | insulin-like growth factor binding protein 7 | 12.2 | 1.82E-15 |
MXRA5 | matrix-remodelling associated 5 | 13.7 | 1.10E-12 |
ITGB6 | integrin, beta 6 | 10.6 | 1.07E-11 |
WNT7A | wingless-type MMTV integration site family, member 7A | 11.7 | 6.96E-11 |
TACSTD2 | tumor-associated calcium signal transducer 2 | 9.4 | 3.31E-09 |
KRT19 | keratin 19, type I | 9.3 | 3.78E-09 |
ESR1 | estrogen receptor 1 | 13.0 | 6.46E-08 |
MUC16 | mucin 16, cell surface associated | 11.6 | 1.23E-07 |
EHF | ets homologous factor | 9.5 | 2.28E-07 |
S100A14 | S100 calcium binding protein A14 | 9.2 | 1.48E-06 |
MAL2 | mal, T-cell differentiation protein 2 | 8.5 | 2.04E-08 |
LAMA3 | laminin, alpha 3 | 7.7 | 1.94E-06 |
ZBED2 | zinc finger, BED-type containing 2 | 9.1 | 6.53E-06 |
LAD1 | ladinin 1 | 9.2 | 3.12E-05 |
IRF6 | interferon regulatory factor 6 | 9.9 | 3.12E-05 |
CFI | complement factor I | 9.2 | 3.35E-05 |
CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 10.1 | 1.09E-04 |
TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | 10.5 | 1.78E-04 |
COL5A1 | collagen, type V, alpha 1 | 8.8 | 7.63E-05 |
MMP2 | matrix metallopeptidase 2 | 8.2 | 8.56E-05 |
PDZK1IP1 | PDZK1 interacting protein 1 | 8.6 | 1.77E-04 |
FAT2 | FAT atypical cadherin 2 | 8.0 | 1.89E-04 |
RNA sequencing analyses was condensed to Gene ID, Gene name, logFC (log2-fold change) and FDR (Benjamini-Hochberg adjusted p-value to account for multiple comparisons). The panel of 23 genes that exhibit the highest logFC and FDR in the three resistant cell lines as compared to the three sensitive lines were selected as the resistant signature.