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. 2017 Dec 26;9(19):14828–14848. doi: 10.18632/oncotarget.23663

Table 1. List of genes representing the resistant genetic signature.

Gene ID Gene name logFC FDR
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 9.9 1.77E-19
IGFBP7 insulin-like growth factor binding protein 7 12.2 1.82E-15
MXRA5 matrix-remodelling associated 5 13.7 1.10E-12
ITGB6 integrin, beta 6 10.6 1.07E-11
WNT7A wingless-type MMTV integration site family, member 7A 11.7 6.96E-11
TACSTD2 tumor-associated calcium signal transducer 2 9.4 3.31E-09
KRT19 keratin 19, type I 9.3 3.78E-09
ESR1 estrogen receptor 1 13.0 6.46E-08
MUC16 mucin 16, cell surface associated 11.6 1.23E-07
EHF ets homologous factor 9.5 2.28E-07
S100A14 S100 calcium binding protein A14 9.2 1.48E-06
MAL2 mal, T-cell differentiation protein 2 8.5 2.04E-08
LAMA3 laminin, alpha 3 7.7 1.94E-06
ZBED2 zinc finger, BED-type containing 2 9.1 6.53E-06
LAD1 ladinin 1 9.2 3.12E-05
IRF6 interferon regulatory factor 6 9.9 3.12E-05
CFI complement factor I 9.2 3.35E-05
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 10.1 1.09E-04
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 10.5 1.78E-04
COL5A1 collagen, type V, alpha 1 8.8 7.63E-05
MMP2 matrix metallopeptidase 2 8.2 8.56E-05
PDZK1IP1 PDZK1 interacting protein 1 8.6 1.77E-04
FAT2 FAT atypical cadherin 2 8.0 1.89E-04

RNA sequencing analyses was condensed to Gene ID, Gene name, logFC (log2-fold change) and FDR (Benjamini-Hochberg adjusted p-value to account for multiple comparisons). The panel of 23 genes that exhibit the highest logFC and FDR in the three resistant cell lines as compared to the three sensitive lines were selected as the resistant signature.