Table 2. List of genes representing the sensitive genetic signature.
| Gene ID | Gene name | logFC | FDR |
|---|---|---|---|
| IGF2BP1 | insulin like growth factor 2 mRNA binding protein 1 | 9.0 | 3.32E-06 |
| ITPRIPL1 | inositol 1,4,5-triphosphate receptor interacting protein-like 1 | 8.5 | 2.96E-05 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | 9.7 | 3.12E-05 |
| CCND2 | cyclin D2 | 11.2 | 1.89E-04 |
| PLAC8 | placenta specific 8 | 6.0 | 3.71E-04 |
| ARHGAP28 | Rho GTPase activating protein 28 | 6.3 | 4.15E-04 |
| SERPINF1 | serpin peptidase inhibitor, clade F, member 1 | 7.9 | 8.03E-04 |
| NOS3 | nitric oxide synthase 3 | 5.1 | 1.49E-03 |
| TBX2 | T-box 2 | 7.4 | 1.68E-03 |
| TEX15 | testis expressed 15 | 7.7 | 2.00E-03 |
| RASGRP2 | RAS, guanyl releasing protein 2 | 7.4 | 2.24E-03 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 6.0 | 3.20E-03 |
| APC2 | adenomatosis polyposis coli 2 | 5.8 | 4.92E-03 |
| COL13A1 | collagen, Type XIII, Alpha 1 | 6.3 | 5.85E-03 |
| FREM2 | Fras1 related extracellular matrix protein 2 | 6.2 | 6.15E-03 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 6.7 | 6.37E-04 |
| MME | membrane metallo-endopeptidase | 5.6 | 9.19E-03 |
| ESPNL | espin-like | 6.1 | 9.31E-03 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 6.1 | 0.01 |
| PDGFRB | platelet-derived growth factor receptor beta | 5.2 | 0.01 |
| SCARF1 | scavener receptor class F member 1 | 5.8 | 0.02 |
| COL3A1 | collagen type III alpha 1 | 7.1 | 0.03 |
| STAG3 | stromal antigen 3 | 6.2 | 0.04 |
RNA sequencing analyses was condensed to Gene ID, Gene name, logFC (log2-fold change) and FDR (Benjamini-Hochberg adjusted p-value to account for multiple comparisons). The panel of 23 genes that exhibit the highest logFC and FDR in the three sensitive cell lines as compared to the three resistant lines were selected as the sensitive signature.