Table 1. Table representing the principal biological characteristics of patients used for the xenograft model.
MDS | Percentage of medullary blasts at diagnostis | Karyotype | Molecular biology | |
---|---|---|---|---|
patient 1 | RAEB-2 | 14 | 46,XY,del(5)(q13q34)[11]/46,sl,add(18)(q21)[9] | TP53 (G245D), SF3B1(R625H), RUNX1 (R201Q) and KIT (D816V) |
patient 2 | RAEB-1 | 4 | 44-45,XY,add(3)(p12),-7,add(17)(p12),mar,min [2]/46,XY [18] | TP53 (G245D) |
patient 3 | RAEB-1 | 6 | 45,X,-Y,del(11)(q21q25)[1]/45,sl,ins(4;3)(q2?6;q28q24)[2]/90,idemx2 [1]/45,sdl1,dic(11;?)(q13;?)[12]/45,sl,t(6;12)(q25;q12),add(11)(q13)[4]/46,XY [2].ish ins(4;3)(EVI1+) | TET2 (R1216X) |
Patient 4 | RARS | 1,5 | 46,XX [20] | SF3B1 (K666R) |
RAEB: Refractory anemia with excess of blast; RARS: Refractory anemia with ring sideroblasts.