Table 2.

Cell Cytotoxicity, Anti–Herpes Simplex Virus Type-1 Activity, and Selectivity Index of the Crude Extract and 4 Corresponding Fractions of Quercus brantii Fruit.^a

Extract	Cell Cytotoxicityb (CC50, μg/mL)	Antiviral Activityc (IC50, μg/mL)	Selectivity Indexd
Crude extract	208	4.3	48.4
n-Hexane fraction	>1000	120.5	>8.3
Chloroform fraction	156.1	2.9	53.8
n-Butanol fraction	112.5	3.8	29.6
Remaining aqueous fraction	330	59	5.6
Acyclovire	177.5	1.3	136.5

^aCell cytotoxicity effect and antiviral activity was determined by MTT assay.

^bCC₅₀ was the concentration that showed 50% cellular cytotoxic effect.

^cIC₅₀ was the concentration that inhibited 50% of HSV-1.

^dSelectivity index is the ratio of CC₅₀ to IC₅₀.

^eAcyclovir was included as positive control for the antiviral activity of HSV-1.