Table 1.

Natural Compounds That Have Direct or Indirect Anti-Angiogenic Potential.

No.	Plant Name	Compound	Possible Mechanism
1	Camellia sinensis (green tea)	EGCG	Abrogates VEGF signaling by interfering with formation of VEGF receptor-2 complex
2	Camptotheca acuminate	Camptothecin	Blocks topoisomerase I, inhibits EC proliferation and tube formation, decreases HIF1α and VEGF expression
3	Combretum caffrum	Combretastatin	Inhibits tubulin assembly
4	Cordyceps militaris	Unknown	Inhibits FGF-2 expression in EC and MMP-expression in tumor cells
5	Ganoderma lucidum	Polysaccharide, peptide	Causes EC apoptosis by reducing Bcl-2 expression and increasing Bax expression, decreases VEGF secretion from tumor cells
6	Glycine max (soybean)	Genistein	Suppresses VEGF and FGF-2 expression, inhibits receptor tyrosine kinase, inhibits activation of NF-κB and Akt signaling pathways
7	Glycyrrhiza uralensis (liquorice)	Isoliquiritin	Inhibits tube formation
8	Panax ginseng	Ginsenosides Rb1	Inhibits VEGF production by tumor cells
9	Sinomenium acutum	Sinomenine	G1-G0 arrest of ECs
10	Salvia miltiorrhiza (danshen)	Cryptotanshinone	G1-G0 arrest of ECs, apoptosis of ECs
11	Taxus brevifolia	Taxol	Disrupts microtubule cytoskeleton inhibits VEGF production, inhibits HIF-1α protein
12	Tripterygium wilfordii Hook.f	Triptolide	Inhibits VEGF expression and secretion from ECs, inhibits COX-1, COX2, and 5-lipoxygenase, decreases transcription of the gene encoding inducible nitric oxides synthase
13	Vinca rosea	Vincristine	Disrupts microtubule cytoskeleton, inhibits VEGF production
14	Vitis spp (grape)	Resveratrol	Disrupts Src-dependent VE cadherin tyrosine phosphorylation