Table 3.

The Effect of Naloxone on the Anticonvulsant Activity of VOEE in PTZ-Induced Convulsion in Mice.

Treatment (Dose)	Onset (s)	Duration (s)	Mortality Protection (%)
Normal saline (10 mL/kg)	57.2 ± 9.45	19.20 ± 0.8	0
Naloxone (5 mg/kg)	83.6 ± 22.83	16.8 ± 2.04	0
VOEE (400 mg/kg)	333 ± 77.40*	10.4 ± 0.25***	100
VOEE + Naloxone	235 ± 82.25	12 ± 0.45	50

Abbreviations: PTZ, pentylenetetrazole; VOEE, Verbena officinalis ethanol extract.

^aNormal saline and VOEE were administered 30 minutes before the injection of PTZ (90 mg/kg, intraperitoneally). Naloxone was administered 35 minutes before the injection of PTZ (90 mg/kg, intraperitoneally). Values are mean ± standard error of the mean for 6 mice.

*P < .05, ***P < .001 compared with the saline group.