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Metabolites formed by N-dealkylation. C–N bond breakage during N-dealkylation creates two metabolites, one from each side of the bond. The nitrogen-side metabolite (R2NH) has a hydrogen in place of the leaving alkyl group. The carbon-side metabolite is an aldehyde/ketone (RCOH/RCOR). Trifluoroacetaldehyde (TFALD) precursor’s site of N-dealkylation is circled.41
