Supplementary Fig. A4.

Neutrophil recruitment to the liver 4 h after intracerebral injection of 100 ng IL-1β. Immunohistochemistry for neutrophils revealed higher numbers of cells in the liver following intracerebral injection of 100 ng IL-1β at all ages compared to naïve or saline injected animals (A). The greatest response was observed in the youngest animals (B). Scale bar = 50 µm. ^∗∗p < 0.01 and ^∗∗∗p < 0.001. ^###p < 0.001 vs. all naïve values, $ significantly different from all saline values, $$ significantly different from 100 ng P21 and P56 and $$$ significantly different from all 100 ng values. P7: n = 3 each group, P14: n = 3 each group, P21: n = 3 each group and P56: n = 4 for naïve and saline, n = 7 for 100 ng IL-1β.