Supplementary Fig. A6.

The effect of experimental activation of the acute phase response on the expression of inflammatory mediators in the striatum 4 h after injection of 1ng IL-1β in the brain. IL-1β and ICAM-1 mRNA expression in the ipsilateral striatum of three different groups of mice: saline i.c + 100 ng i.v., 1ng i.c + saline i.v. and 1ng i.c. + 100 ng i.v. Data are represented as relative fold change from expression levels of 1ng i.c + saline i.v. group of mice. Note: no significant difference in inflammatory gene expression was observed in the brain in these treatment groups, in contrast to the large difference in gene expression observed in the liver. i.v.: intravenous, i.c.: intracerebral. Saline i.c./100 ng i.v.: n = 3, 1ng i.c./saline i.v.: n = 4 and 1ng i.c./100 ng i.v.: n = 4.