Variable	Human granulocytic anaplasmosis	Lyme disease	Babesiosis
Clinical presentation	Flu-like symptoms, headache, gastrointestinal symptoms	Localized: flu-like symptoms, lymphadenopathy Disseminated: rheumatologic, cardiac, neurologic complications	Flu-like symptoms, anorexia, nausea, hepatosplenomegaly, psychiatric symptoms
Rash	Uncommon	Erythema migrans at site of tick bite	Uncommon
Laboratory	Thrombocytopenia, leukopenia, mild anemia, moderate transaminitis	Normal hematologic panel, mild transaminitis	Thrombocytopenia, hemolytic anemia, acute kidney injury, mild transaminitis
Treatment*	Doxycycline, 100 mg orally, twice per day		Atovaquone, 750 mg orally, twice per day, or azithromycin, 250–1000 mg orally, daily
Duration of treatment, d	10–14	14–21	7–10

^*Treatment of disseminated Lyme involves parenteral therapy.