Table 3.
Immune BAL Mediator Levels between Age Groups (pg/ml fluid)
| Immune Mediator |
Total (n=91) |
<50 years (n=50) |
50–64 years (n=21) |
>65 years (n=20) |
p-value | p-value* |
|---|---|---|---|---|---|---|
| IL-1β | 20.3 (2.8–105.4) |
13.7 (2.2–88.6) |
53.0 (7.4–133.7) |
15.4 (2.5–71.3) |
0.40 | 0.72 |
| IL-1RA | 219.8 (108.1–476.3) |
215.2 (91.2–729.7) |
247.1 (107.0–479.9) |
219.6 (153.5–358.5) |
0.98 | 0.66 |
| IL-2 | 0.7 (0.0–3.0) |
0.6 (0.0–3.5) |
1.1 (0.1–2.3) |
0.7 (0.0–3.8) |
0.75 | 0.98 |
| IL-4 | 1.1 (0.04–2.9) |
1.2 (0.1–2.9) |
1.1 (0.0–3.2) |
1.1 (0.0–2.9) |
0.95 | 0.42 |
| IL-6 | 175.5 (52.2–517.5) |
243.9 (50.9–541.5) |
136.4 (40.4–386.4) |
178.8 (66.5–318.1) |
0.64 | 0.32 |
| IL-8 | 1943.5 (527.1–5816.8) |
1776.9 (263.8–4969.2) |
2393.3 (391.6–8067.3) |
2347.7 (984.6–4068.7) |
0.60 | 0.28 |
| IL-10 | 7.3 (3.0–13.7) |
7.4 (3.0–20.4) |
8.1 (3.1–11.7) |
5.6 (2.7–8.9) |
0.45 | 0.09 |
| IL-12 | 11.2 (0.0–27.8) |
15.6 (0.5–34.0) |
6.9 (0.0–21.2) |
9.9 (0.0–21.6) |
0.34 | 0.28 |
| IL-13 | 3.1 (1.4–5.3) |
3.1 (1.1–5.3) |
3.1 (1.9–5.4) |
3.2 (1.2–4.3) |
0.83 | 0.73 |
| IL-17 | 0.0 (0.0–10.0) |
0.0 (0.0–11.8) |
0.0 (0.0–8.3) |
0.0 (0.0–0.6) |
0.61 | 0.20 |
| Eotaxin | 42.1 (0.8–78.8) |
45.5 (0.0–78.3) |
27.8 (7.4–69.3) |
42.3 (0.0–105.9) |
0.96 | 0.44 |
| G-CSF | 127.7 (56.3–390.7) |
169.5 (66.0–415.2) |
163.3 (62.7–323.2) |
85.1 (46.2–337.1) |
0.52 | 0.81 |
| GM-CSF | 7.9 (0.0–42.3) |
14.9 (0.1–51.1) |
4.2 (0.0–30.5) |
7.6 (0.0–68.3) |
0.58 | 0.72 |
| IFN-γ | 35.9 (8.0–92.7) |
27.6 (7.3–110.7) |
36.6 (0.7–82.0) |
41.5 (12.1–89.6) |
0.80 | 0.65 |
| IP-10 | 1072.8 (405.3–2101.5) |
1117.8 (436.8–2317.5) |
760.6 (388.7–1773.1) |
1019.7 (433.2–1829.3) |
0.69 | 0.97 |
| MCP-1 | 123.4 (47.0–374.8) |
92.8 (34.8–266.7) |
81.5 (47.5–233.2) |
351.2 (123.4–1417.1) |
0.003 | 0.05 |
| TNF-α | 17.4 (0.2–65.8) |
23.6 (3.7–62.8) |
22.6 (0.0–88.0) |
11.7 (0.0–65.8) |
0.75 | 0.69 |
Data represented as median with 25%–75% interquartile range; all values are pg/ml; Univariable comparison of continuous variables by Kruskal-Wallis test.
*
Multivariable linear regression adjusting for age group, sex, race, % TBSA, and inhalation injury grade. Adjusted p-value is for the age group over 65 years compared to referent group <50 years. IL, interleukin; IL-1RA, interleukin-1 receptor antagonist; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN-γ, interferon-gamma; IP-10, interferon-gamma-inducible protein 10; MCP-1, monocyte chemoattractant protein 1; TNF-α, tumor necrosis factor alpha