Table 5.
Unadjusted and Adjusted Association between Immune Mediator in BAL (pg/mL fluid) and In-Hospital Death
| Immune Mediator | Unadjusted OR (95% CI) |
p-value | Fully adjusted OR (95% CI) |
p-value |
*Stratified to Age >65 (95% CI) |
p-value |
|---|---|---|---|---|---|---|
|
| ||||||
| IL-1β, 100 pg/ml | 0.99 (0.86–1.16) |
0.96 | 1.03 (0.84–1.26) |
0.77 | 0.95 (0.62–1.46) |
0.83 |
| IL-1RA, 100 pg/ml | 0.99 (0.92–1.07) |
0.83 | 0.98 (0.89–1.10) |
0.82 | 0.98 (0.81–1.20) |
0.87 |
| IL-6, 100 pg/ml | 1.01 (0.96–1.06) |
0.81 | 1.01 (0.88–1.16) |
0.87 | 1.15 (0.88–1.50) |
0.30 |
| IL-8, 100 pg/ml | 0.99 (0.98–1.01) |
0.25 | 0.98 (0.97–1.01) |
0.08 | 0.97 (0.88–1.06) |
0.51 |
| IL-10, 25 pg/ml | 0.23 (0.04–1.23) |
0.09 | 0.12 (0.01–1.91) |
0.13 | 0.01 (0.01–14.82) |
0.16 |
| IL-12, 100 pg/ml | 0.81 (0.26–2.56) |
0.72 | 0.71 (0.05–11.06) |
0.80 | 0.08 (0.01–130.83) |
0.51 |
| IL-13, pg/ml | 0.99 (0.88–1.11) |
0.80 | 0.86 (0.62–1.20) |
0.86 | 0.86 (0.60–1.24) |
0.42 |
| IL-17, pg/ml | 0.97 (0.92–1.02) |
0.21 | 1.00 (0.90–1.12) |
0.94 | 0.93 (0.73–1.18) |
0.54 |
| Eotaxin, 25 pg/ml | 1.10 (0.90–1.32) |
0.36 | 1.31 (0.89–1.92) |
0.18 | 3.73 (0.63–22.18) |
0.15 |
| G-CSF, 100 pg/ml | 0.89 (0.75–1.06) |
0.89 | 0.73 (0.43–1.23) |
0.23 | 0.84 (0.57–1.22) |
0.36 |
| GM-CSF, 100 pg/ml | 1.03 (0.31–3.40) |
0.96 | 0.23 (0.01–5.56) |
0.40 | 0.23 (0.01–13.49) |
0.48 |
| IFN-γ, 100 pg/ml | 1.02 (0.54–1.89) |
0.96 | 0.87 (0.26–3.00) |
0.83 | 1.36 (0.32–5.75) |
0.67 |
| IP-10, 100 pg/ml | 0.99 (0.98–1.02) |
0.95 | 1.01 (0.98–1.05) |
0.57 | 0.99 (0.94–1.04) |
0.67 |
| MCP-1, 25 pg/ml | 1.01 (0.99–1.02) |
0.21 | 1.08 (0.98–1.19) |
0.13 | 1.03 (0.99–1.06) |
0.14 |
| TNF-α, 100 pg/ml | 0.82 (0.40–1.67) |
0.58 | 0.69 (0.14–3.47) |
0.65 | 0.63 (0.10–4.16) |
0.63 |
Multivariable linear regression adjusting for age group, sex, race, %TBSA and inhalation injury grade was used for the fully adjusted model.
*
This model was then stratified to the subjects ≥ 65 years.
IL, interleukin; IL-1RA, interleukin-1 receptor antagonist; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN-γ, interferon-gamma; IP-10, interferon-gamma-inducible protein 10; MCP-1, monocyte chemoattractant protein 1; TNF-α, tumor necrosis factor alpha