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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Curr Opin Genet Dev. 2017 Nov 10;48:57–66. doi: 10.1016/j.gde.2017.10.008

Figure 3.

Figure 3

SF3B1 (cyan) has recurrent acquired mutations (yellow) in myeloid neoplasms and cancers, here mapped on the (a) domains and (b) structure of the Baker’s yeast homologue in the BACT complex (PDB ID 5GM6). Residues matching human SF3B1 were identified by superposition with the SF3B particle (PDB ID 5IFE). Mutational hotspots (yellow), residues for which mutations confer resistance to splicing modulators (green), and branchpoint (BP) are labeled. The bound pre-mRNA is magenta, the U2 snRNA strand is black, and the surface of the PHF5A subunit is colored light gray.