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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Curr Opin Genet Dev. 2017 Nov 10;48:57–66. doi: 10.1016/j.gde.2017.10.008

Figure 4.

Figure 4

U2AF1 (cyan) has recurrent acquired mutations (yellow) in MDS and cancers, here mapped on the (a) domains of the human protein and (b) structure of the fission yeast homologue (PDB ID 4YH8). Four structures contain zinc knuckles (ZnK) bound to RNA: (c) MBNL1 (PDB ID 3D2S), (d) TIS11d (PDB ID 1RGO), (e) CWC24 (PDB ID 5GM6), (f) CWC2 (PDB ID 5GMK). The ZnK orientations are identical among panels (c)–(f). For MBNL1 and TIS11d, both of the two ZnK in each structure are shown following superposition of matching Cα-atoms. The residues corresponding to Q157 (left) and S34 (right) are yellow spheres. Gray spheres represent zinc ions. The 5′ termini of the bound RNAs (magenta) are labeled to indicate the different orientation of TIS11d-bound RNA.