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. 2018 Mar 10;10(1):47–59.

Figure 2.

Figure 2

(A-D) EP1 receptors ligand effects on Na+, K+-ATPase activity in the brain. ONO-DI-004 (10 µg/kg, s.c.) increases (A) and ONO-8713 (10 µg/kg, s.c.) prevents (B) PTZ-induced decrease of Na+, K+-ATPase activity in cerebral cortex and hippocampus homogenates in mice. Data are presented in nmol Pi/mg protein/min, as mean + S.E.M., for n = 5 in each group. Data were analyzed by a two-way ANOVA followed by the Bonferroni’s test. (C) ONO-DI-004 (3 µg/kg, s.c.) does not present per se effect on Na+, K+-ATPase (P > 0.05 by Student’s t-test, for n = 5). (D) Two-way ANOVA followed by the Bonferroni’s test revealed that ONO-DI-004 (3 µg/kg, s.c.) accentuated PTZ-induced decrease of Na+, K+-ATPase activity and prevented ONO-8713 (10 µg/kg, s.c.) effect on this enzyme activity in cerebral cortex and hippocampus homogenates in mice. Data are presented in nmol Pi/mg protein/min, as mean + S.E.M., for n = 5 in each experimental group. *P < 0.05, when compared with the respective control group; #P < 0.05, when compared with vehicle group.