Table 2.
Concentrations of aminoacids, haemoglobin, C-reactive protein, and haemolytic markers and measures of endothelial and non-endothelial dependent vascular function before and after RUSF treatment
| Baseline | RUSF-v | RUSF-b | Washout 1 | |
|---|---|---|---|---|
| Aminoacid concentrations | ||||
| Arginine, μmol/L | 54·40 (51·71–57·22) | 83·27 (75·13–92·29) | 61·84 (58·57–65·29) | .. |
| Citrulline, μmol/L | 24·53 (23·41–25·70) | 25·52 (22·91–28·41) | 21·59 (20·68–22·53) | .. |
| Ornithine, μmol/L | 51·54 (47·85–55·52) | 76·50 (69·61–84·08) | 54·44 (51·59–57·44) | .. |
| Asymmetric dimethylarginine, μmol/L | 0·98 (0·91–1·06) | 0·83 (0·79–0·88) | 0·82 (0·76–0·88) | .. |
| Arginine to ornithine ratio | 1·06 (0·98–1·14) | 1·09 (1·03–1·15) | 1·14 (1·08–1·20) | .. |
| Global arginine bioavailability ratio | 0·70 (0·67–0·74) | 0·81 (0·77–0·85) | 0·80 (0·77–0·84) | .. |
| Arginine to asymmetric dimethylarginine ratio | 53·74 (49·54–58·29) | 99·78 (89·93–110·70) | 75·50 (69·19–82·38) | .. |
| Endothelial function* | ||||
| Flow-mediated dilatation, % | 7·66% (7·04–8·27) | 8·60% (7·97–9·23) | 8·10% (7·53–8·66) | 7·70% (7·11–8·29) |
| Brachial artery diameter at rest, mm | 2·61 (2·55–2·67) | 2·64 (2·58–2·71) | 2·70 (2·63–2·78) | 2·63 (2·56–2·70) |
| Baseline blood flow (VTI), m | 0·20 (0·18–0·22) | 0·22 (0·20–0·24) | 0·24 (0·22–0·25) | 0·19 (0·18–0·21) |
| Absolute reactive hyperaemia, m | 0·69 (0·65–0·73) | 0·77 (0·73–0·81) | 0·78 (0·74–0·81) | 0·78 (0·75–0·82) |
| Endothelium-independent vasodilatation* | ||||
| Response to glyceryl trinitrate, % | 4·22% (3·81–4·64) | 4·41% (4·04–4·78) | 4·51% (4·10–4·92) | 4·77% (4·43–5·11) |
| Blood markers | ||||
| Haemoglobin, g/dL* | 7·5 (7·3–7·7) | 7·6 (7·4–7·8) | 7·7 (7·6–7·9) | 7·3 (7·1–7·4) |
| C-reactive protein, mg/L | 3·35 (2·95–3·81) | 3·84 (3·21–4·59) | 3·94 (3·25–4·79) | 3·51 (2·90–4·25) |
| Lactate dehydrogenase, IU/L | 566 (548–585) | 611 (576–649) | 596 (561–633) | 545 (519–573) |
| Total bilirubin, mg/dL | 38·07 (35·44–40·89) | 34·34 (30·00–39·32) | 36·88 (32·80–41·48) | 38·95 (34·93–43·43) |
| Non-conjugated bilirubin, mg/dL | 27·03 (24·81–29·45) | 24·53 (21·29–28·25) | 24·93 (21·55–28·85) | 27·94 (24·50–31·85) |
Data are geometric mean (95% CI) and are natural log-transformed, unless otherwise indicated. RUSF=ready-to-use food supplement. v=vascular. b=basic.
*
Mean (95% CI).