Table 2.
Tissue content of DA, DOPAC, HVA, 5-HT, and 5-HIAA in the mouse striatum and frontal cortex measured 3 h after cessation of treatment with drugs
| Treatment | DA | DOPAC | HVA | 5-HT | 5-HIAA |
|---|---|---|---|---|---|
| Striatum (pg/mg wt) ± SEM (n) | |||||
| Control | 9206 ± 568 (11) | 913 ± 40 (11) | 1016 ± 31 (11) | 458 ± 30 (11) | 353 ± 16 (11) |
| CAF | 10,929 ± 728 (11)* | 631 ± 44 (11)* | 1141 ± 95 (11) | 495 ± 33 (11) | 362 ± 19 (11) |
| MDMA | 11,175 ± 740 (11)* | 447 ± 28(11)* | 962 ± 35 (11) | 435 ± 26 (11) | 238 ± 11 (11)* |
| CAF+MDMA | 16,292 ± 2246 (5)*,**,*** | 595 ± 74 (5)*,** | 1169 ± 142 (5) | 447 ± 55 (5) | 191 ± 18 (5)*,**,*** |
| Frontal cortex (pg/mg wt) ± SEM (n) | |||||
| Conrol | 1086 ± 90 (11) | 133 ± 10 (11) | 221 ± 13(11) | 450 ± 24(11) | 154 ± 7(4) |
| CAF | 1215 ± 121 (11) | 130 ± 11 (11) | 238 ± 14(11) | 435 ± 20(11) | 160 ± 10(11) |
| MDMA | 1284 ± 80 (11) | 106 ± 8 (11)* | 219 ± 15(11) | 453 ± 44(11) | 129 ± 12(11)* |
| CAF+MDMA | 1224 ± 160 (4) | 81 ± 6 (11)*,**,*** | 205 ± 14(4) | 496 ± 33(4) | 130 ± 2(4)* |
Values are the mean ± SEM (n)
*P < 0.001 vs. control; **P < 0.001 vs. MDMA; ***P < 0.001 vs. CAF (one-way ANOVA and Tukey’s post hoc test)