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. 2018 Mar 21;9:91. doi: 10.3389/fendo.2018.00091

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Copyright © 2018 Berberich, Dietrich, Hoermann and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FT₃-plots $[\frac{pmol}{l}]$ over a simulation horizon of 25 days for several configurations of the TSH-T₃-Shunt. The parameters G_T₃ and G_D₁ are identified via least squares optimization, separately for each model configuration. (A) No shunt included. (B) Full TSH-T₃-shunt.