Figure 1.

Schematic depiction of two immune-evasion mechanisms. PMN (purple) with granula and fungal cells are either alive (green), killed (red), or immune evasive (gray). (A) Illustration of spontaneously evading fungal cells. (B) Illustration of the PMN-mediated immune-evasion mechanism, which is associated with degranulation on first-time phagocytosis of fungal cells by PMN. Degranulation is assumed to mediate the release of proteins into extracellular space that enables fungal cells to evade subsequent killing and phagocytosis by modification of their surface.