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. 2018 Mar 21;12:183. doi: 10.3389/fnins.2018.00183

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Copyright © 2018 Martinon and Dabrowska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OT content in BNST_dl microdialysates is modulated by CRF. CRF caused a significant increase in OT release at 90 min (n = 9, red triangle, P < 0.001 in comparison to ACSF group). CRFR1 blockade by NBI 35965 did not significantly affect the effect of CRF on OT release (n = 8, cyan, open square, P > 0.05). However, blocking CRFR2 with As2B abolished the effect of CRF on OT release (n = 7, blue diamond, P < 0.01). ^***P < 0.001, ^**P < 0.01 two-way ANOVA with repeated measures.