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Proposed Model for hNetrin-1- and Draxin-Mediated Adhesion between Axons through DCC
Two opposing axons decorated with DCC (orange, individual Ig domains depicted as ovals and fibronectin domains as boxes). hNetrin-1 (different shades of blue) binds DCC at the laminin (VI) domain as well as the EGF domains (sites 1 and 2). Draxin (purple) competes with DCC to bind hNetrin-1 at site 1 and crosslinks hNetrin-1 with a DCC molecule on the opposite axon.
